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The only part that requires SSE 4.2 is the CPU platform. Everything else (the reference, CUDA, and OpenCL platforms) can work without it.
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SimTK is maintained through Grant R01GM124443 01A1 from the National Institutes of Health (NIH). It was initially developed as part of the Simbios project funded by the NIH as part of the NIH Roadmap for Medical Research, Grant U54 GM072970.