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Local RNA structural changes induced by crystallization are revealed by SHAPE Q. Vicens, A. R. Gooding, A. Laederach, T. R. Cech RNA (2007), 13 (4), 536-548 (2007)    View

noRNAlize normalizes SHAPE footprinting data


This project is a data analysis package to analyze and normalize SHAPE data. Traditionally, SHAPE requires the addition of a 3' hairpin to the RNA for normalization. noRNAlize elminates the need for this experimental step by performing a global analysis of the SHAPE data, and establishing mean protection values. This is particularly important when SHAPE analysis is used to map crystal contacts in crystal structures as illustrated here.

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This download enables pairwise normalization of chemical probing data obtained using techniques like SHAPE.
This download is to complement SAFA and contains files to use in Matlab.

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