The goal of this project was to develop the first detailed, "whole-cell" computational model of the entire life cycle of living organism, Mycoplasma genitalium
. The model describes the dynamics of every molecule over the entire life cycle and accounts for the specific function of every annotated gene product.
We anticipate that whole-cell models will be critical for synthetic biology and personalized medicine. Please see the project website wholecell.org
and the Downloads page to explore the whole-cell knowledge base and simulations and obtain the model code.
Available Downloads and Their Potential Uses: This project provides all code and training data for the M. genitalium whole-cell model and all experimental and computational results described in Karr et al., 2012.
Purpose/Synopsis: This project provides all code and data for the first "whole-cell" model of the entire life cycle of a living organism, Mycoplasma genitalium.
Audience: Experimental and computational researchers interested in comprehensive, detailed modeling of single cells and populations.
Long Term Goals and Related Uses: Develop the comprehensive and detailed computational models of single cells and populations that will enable synthetic biology and personalized medicine.
Ontology Classification: Algorithm, Computational_Model, Database, Knowledgebase, Modeling_and_Simulation, Network_Model, Numerical_Model, Phenotypic_Measurement, Software, Website
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Keywords: bacteria, cell biology, cell physiology, computational biology, genotype to phenotype, mycoplasma genitalium, systems biology
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