The study explored the intestinal flora of patients with type 2 diabetes (T2DM) during low-fat diets by 16S high-throughput sequencing. Group C is the intestinal flora of healthy individuals which is a control. Group T0-T3 is the intestinal flora of T2DM patients. T0, T1, T2, and T3 are the composition of the intestinal flora at the time of initial diagnosis, 1 month, 3 months, and 6 months after low-fat diet treatment. In addition, blood glucose and other data of T2DM patients were added to the table.