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The goal of this project is to implement a model of the Winding Filament Hypothesis of muscle contraction (Nishikawa, 2012) for use in OpenSim. The Winding Filament Hypothesis states that upon calcium influx into the muscle sarcomere, titin binds to and w


The goal of this project is to implement a model of the Winding Filament Hypothesis of muscle contraction (Nishikawa, 2012) for use in OpenSim. The Winding Filament Hypothesis states that upon calcium influx into the muscle sarcomere, titin binds to and winds upon actin thin filaments. The mechanical behavior of titin could serve as an explanatory mechanism for force enhancement with stretch, force depression with shortening, and dynamic force-velocity properties of active muscle.
The Winding Filament Model (WFM) is a two parameter model (resting length and peak isometric force) comprised of a pulley of radius R, about which a damped contractile element, a damped titin spring element, and a series elastic element interact. The pulley rotates and translates in response to applied forces, internal model forces, and changes in length. Current implementation in OpenSim is through the MATLAB scripting interface, with the goal of this project being a freely distributed WFM plug-in utilizing all features currently offered within the OpenSim 3.3 API.

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