Explain AILI attributes measured from wet-lab experiments using virtual experimentation on concrete, biomimetic, agent-based mouse models called analogs.
The AILI project is a type of In-Silico Liver (ISL) project, which consists of a body of Java code used and reused for exploring hypothetical liver mechanisms. For AILI, the liver mechanisms are those that cause cellular damage, specifically necrosis, because of exposure to acetaminophen. Moreover, the model, a mouse analog, is used for virtual experimentation to explore and explain AILI phenomena, analogous to wet-lab experimentation. A recent addition to this project is studying the disconnect between in vitro and in vivo wet-lab experiments by comparing and contrasting virtual Mouse and Culture Analogs.
We expect pre-configured analogs, used to derive published data, to be downloaded and experiments to be repeated by readers.
We expect the code to be read, modified, recompiled and reused by interested researchers.
And we expect researchers at other labs to fork the project as well as contribute workflow, requirements, model, and code changes.